Moonlighting cytochrome P450 monooxygenases
نویسندگان
چکیده
منابع مشابه
Versatile biocatalysis of fungal cytochrome P450 monooxygenases
Cytochrome P450 (CYP) monooxygenases, the nature's most versatile biological catalysts have unique ability to catalyse regio-, chemo-, and stereospecific oxidation of a wide range of substrates under mild reaction conditions, thereby addressing a significant challenge in chemocatalysis. Though CYP enzymes are ubiquitous in all biological kingdoms, the divergence of CYPs in fungal kingdom is man...
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Cytochrome P450 monooxygenases (P450s) mediate a wide range of oxidative reactions involved in the biosynthesis of plant secondary metabolites including phenylpropanoids and phytoalexins. To investigate the regulation of these P450s in the phenylpropanoid biosynthetic pathway of pea (Pisum sativum), partial cDNAs representing four distinct P450s expressed in pea seedlings were cloned using a re...
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Plants and herbivorous insects interact at the most fundamental of levels. With few exceptions, in the battle waged daily between these two groups of organisms, one serves as food source, the other as consumer. From a plant’s perspective, success in this interaction is measured by its ability to defend itself from devastation by insect feeding. From an insect’s perspective, success is measured ...
متن کاملCytochrome P450 monooxygenases as reporters for circadian-regulated pathways.
Cytochrome P450 monooxygenases (P450s) play important roles in the synthesis of diverse secondary compounds in Arabidopsis (Arabidopsis thaliana). Comparison of four data sets analyzing seedlings harvested over a 2-d period of constant conditions after growth with varying photoperiods and thermocycles recorded a total of 98 P450 loci as circadian regulated for at least one of the four condition...
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In this work, the role of genetic as well as environmental factors in determining cytochrome P450 isozyme levels in man have been studied. Simple DNA based assays for the identification of individuals nulled at the CYP2D6 locus are described and have been applied to investigate whether this gene defect is associated with altered cancer susceptibility. In contrast to literature reports, in no ca...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2011
ISSN: 1521-6543
DOI: 10.1002/iub.501